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KMID : 0043319820050020039
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Archives of Pharmacal Research
1982 Volume.5 No. 2 p.39 ~ p.43
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An Antitumor Component of Laetiporus sulphureus and its Immunostimulating Activity
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Kang CY
Lee CO/Chung KS/Choi EC/Kim BK
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Abstract
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A protein-polysaccharide fraction was prepared from the carpophores of Laetiporus sulphureus. This fraction suppressed growth of sarcoma 180 in A-strain mice when administered i.p. To investigate the mechanism of antitumor action of this fraction, plaque assay was conducted by administrating i.p. to the mice at a dose level of 50mg/kg for five days. Ten days later, the mice were immunized with 1 X 107 sheep red blood cells. The number of hemolytic plaque forming cells was significantly greater than that of the control mice. Three monosaccharides and fifteen amino acids were identified in the protein-polysaccharide fraction.
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